A common transition in MTHFR gene and male infertility: a meta-analysis in Iranian population Download PDF

Male infertility is a main issue for juvenile couples. About 50% of infertility causes refer to male factors. Genetic factors such as genetic polymorphisms in key genes could affect male infertility. One of key gene polymorphisms is MTHFR-C677T which may influence male infertility. There are three case-control study about the association of C677T transition with male infertility in Iranian population, but the results are approximately inconclusive. Therefore, we performed a meta-analysis in Iranian population about the association of C677T transition with male infertility. We found the eligible studies by search in suitable databases. Then, the data was extracted from included studies and was analyzed by Open Meta [analyst] Software. Our data revealed that there is a significant association of MTHFR-C677T with male infertility in TT vs. CC (OR= 2.197, 95%CI= 1.431- 3.372, p< 0.001, Pheterogeneity= 0.526, I2= 0%) and CT vs. CC (OR= 1.472, 95%CI= 1.156-1.875, p= 0.002, Pheterogeneity= 0.767, I2= 0%) models within Iranian population. According to our results, MTHFR-C677T may be a strong biomarker for screening of susceptible infertile men in Iranian population.