A Comprehensive Review of Irritable Bowel Syndrome Screening Models for Drug Research and Development Download PDF

IBS is a common digestive disorder (IBS). It is marked by visceral, hypersensitivity, and an alter in bowel habits. It is mostly caused by smoking, stress, variations in gut flora, and genetic variants. Because there is currently no particular treatment to cure IBS, it is critical to evaluate the benefits and drawbacks of existing IBS animal models, utilize these models, and construct better models for drug research and development.  The main goal of this paper is to study different models of irritable bowel syndrome to recreate IBS symptoms and find the molecular mechanisms that cause the disorder and utilize them in the development of medications that have the potential to be useful in the treatment of IBS. The report's material was generated from review articles and research papers from 1981 to 2021 using keywords like Stress, Brain-gut axis, Trinitrobenzene sulfonic acid, Acetic acid and so on. IBS has no recognized cause or treatment. so, using these models to build successful IBS medication. The pathogenesis of IBS is still poorly understood and psychosocial stress of various origins has been assigned a significant impact. As psychosocial stressors, animal models such as neonatal mother separation, water avoidance stress, and wrap restraint stress have been created to mimic IBS symptomatology and discover the biological pathways associated with the disease. In addition, other models such as antidiarrheal and anti-inflammatory are also used. The investigation of these models has resulted in the development of medications that may be efficacious in IBS management.