This research is a descriptive-correlational study aimed at investigating the relationship between pain self-efficacy and emotional intelligence with resilience in patients with leukemia. The statistical population consisted of all the patients suffering from leukemia in Neyshabour. The statistical sample comprised all the leukemia patients with a treatment file in the chemotherapy center of 22 Bahman Hospital in Neyshabour during March to May (Farvardin to Khordad) of 2016, who were selected through full enumeration. In this study, Nicholas Pain Self-Efficacy Questionnaire (1989), Goleman Emotional Intelligence Questionnaire (1995) and Connor-Davidson Resilience Scale (2003) were used for data collection. To analyze the data, Pearson correlation coefficient test and multivariate regression were applied. The obtained results demonstrated that pain self-efficacy and emotional intelligence can predict resilience in leukemia patients. Further, the findings suggested that there is a significant relationship between pain self-efficacy and emotional intelligence with resilience in patients with leukemia.