A Review on Fast Dissolving Drug Delivery System: Taking Advantage of Nanofibers Download PDF

Fast-dissolving drug delivery systems (FDDDS) have recently gained attention and acceptance as a new oral drug delivery system. The aim of FDDDS is to enhance the safety and efficacy of conventional oral dosage forms and increase the patient compliance. This system was used initially in confectionery and oral care markets in the form of breath strips. Recently, large number of pharmaceutical industries are interested in this formulation due to high consumer acceptance. FDDDS is a type of drug delivery system that when is placed on tongue drug dissolves in the saliva and releases the drug immediately without the need of water or chewing. Due to unique properties, easy and effective preparation methods of electrospun nanofibers, they demonstrate great potential for developing various novel drug delivery systems (DDS). Currently, electrospun nanofiber-DDS are focused on preparation of drug-loaded nanofibers from different biodegradable polymers and various types of DDS. Although, electrospinning process and resulting drug-loaded nanofibers DDS have greater potential to be exploited.