Kidney harm is most vital health issues and lots of herbal medicines are involved in case of kidney injury. World health organization (WHO) estimate that eightieth of total population used herbal drugs for some characteristic of primary health care while not any facet effects. Herbal medicine has emerged as a skilled approach with sensible values in handling various diseases and developing an affordable phytotherapy to treat severe kidney diseases. The use of herbs as nephroprotective is a major avenue in Indian perspectives particularly for treating kidneys damage, which require to be explored more successfully as there are many literatures available on these aspects. The current review is aimed toward collecting information on promising active phytoconstituents like alkaloids, benzoquinones, catechols, carotenoids, flavonoids, glycosides, flavonol glycosides, steroid glycosides, glycoalkaloids, terpenoids, monoterpenoids, diterpenoids, triterpene saponins, sterols and polyphenols from medicinal plants that are tested in nephroprotective models exploitation fashionable scientific system.