The Transdermal Drug Delivery Systems (TDDS), which have evolved as elements of the creation of innovative drug administrative systems, is the most important aspect of pharmaceutical dosage. The use of Transdermal patches has a systemic influence due to the penetration of the drug through the dermis. TDDS is also necessary due to its distinctive benefits. Sustained absorption, more constant plasma concentration, less first-pass metabolism, lower adverse outcomes, quick application, and the mouldability to cease medicines easily by clipping out the skin patches are some of the potential positives of transdermal pharmaceutical delivery. This method of drug delivery has many benefits over conventional oral and intravenous techniques. Ensure the fluid is released in a controlled manner with long-term treatment using drugs. As a result, numerous chemical and physical methods for developing transdermal patches are being investigated. The therapeutic application of first-generation transdermal delivery systems has steadily increased for the administration of tiny, lipophilic, low-dose medicines. Second-generation delivery systems that include chemical enhancers, non-cavitational ultrasound, and iontophoresis regulate administration rates in real-time. Third generation TDDS enhanced permeability of drugs through stratum corneum using microneedle, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound technology. This review article explains how to make different types of transdermal patches. Multiple ways for measuring transdermal dosage and the progression of TDDS were also investigated.