The present research aims at studying the relationship between personality traits, quality of life and spiritual health of nurses who work in Imam Reza Hospital of Kermanshah. The research methodology is descriptive and correlational in nature. The research population consists of all nurses who work in Imam Reza Hospital of Kermanshah during 2016 among which 200 nurses were selected as the research sample according to Cochran formula. As far as the theoretical aspects are concerned, the research data gathering tools were documentary and library studies. Also, three standard questionnaires were used for the research analytical aspects, namely, Paloutzian and Ellison`s spiritual health questionnaire (1982), the World Health Organization`s questionnaire of quality of life (1998) and NEO personality inventory and its revised version (i.e. NEO five-factor) introduced by McCrae and Costa. Then, the data were analyzed using indicators and methods of descriptive statistics and inferential statistics including correlation coefficient and multivariate regression by using the SPSS22 software. Results showed a significant relationship between personality traits and quality of life of nurses. Also, there was significant relationship between personality traits and spiritual health of nurses. Moreover, the author concluded that personality traits can predict nurses` quality of life and spiritual health.