A Systematic Review of Spherical Agglomeration by Particle Design of Drug Formulation Download PDF

Particle design through various Spherical Agglomeration techniques used for many bulks and fine manufacturing industries with the latest temptation into pharmaceuticals with size modification. By this an addition of an immiscible bridging liquid to the formation of agglomerate crystals beforedeliquoring. The spherical agglomeration method can produce high-performance spherical shape particles in a single crystallization unit, even though it is quitechallenging to control the particle size and shape.Multi-liquid phases play important role in dynamic balance among the intensity of adhesion, dispersion, and capillary action.The search terms spherical agglomeration, spherical crystallization, and drug formulation by spherical agglomeration were used to recognize peer-reviewed publications restricted to the English language in PubMed and Web of Science electronic databases issued from initiation until January 2022. A total of 606 publications were found, of which 24 met the inclusion criteria after all exclusion screening. The review showed that Spherical agglomeration techniques exhibited decreased crystallinity and design particle size and shape. The amount of bridging liquid along with the multi-liquid phase and various mechanical factors affects the characteristics of spherical particles. An in vitro and in vivo study depicts the effectiveness of spherical agglomeration techniques in many parameters like improved bioavailability and other compression parameters..