Adipokines and Insulin Resistance; The important role of Leptin, Adiponectin and Interleukin-6
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Reza Mohammadpourhodki1, Arezou Salari2, Hossein Balesh Abadi3, Sanaz Noura4, Zahra Ashrafi5, Amir Mahdi Iranshahi*6, Nasim SHirmohammadi7
Abstract
Adipose tissue (AT) was believed to be just an energy-storage organ, but it is now recognized to be an active organ, which secretes a variety of products known as “adipokines” such as leptin and adiponectin, as well as cytokines and chemokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6. The adipokines have broad activities on metabolical pathways, endothelial function and inflammation and are implicated in the pathogenesis of several disorders, particularly insulin resistance.
