Thespesia populnea is also called as Indian tulip tree, poovarasu, is tropically distributed plant. In the present study of ethanolic extract of flowers of Thespesia populnea was screened for anti-inflammatory and antioxidant activities. Anti-inflammatory activity of ethanolic extract was determined by HRBC and Albumin denaturation method. Anti-oxidant activity of ethanolic extract was determined by DPPH assay and ABTS method. The results of the study suggest that the ethanolic extract possesses anti-oxidant and anti-inflammatory activity.