Pharmacophore
Search Aim and Scope Editorial Board Author Guidelines Indexing
Pharmacophore an International Research Journal
Home About Archive
Policies
Privacy Statement Peer Review Editorial Policies Publishing Ethics Copyright and Access Open Access Conflicts of Interest
Contact Us Submission
Pharmacophore
Submit Manuscript
Open Access | Published: 2023 - Issue 1

Anticancer Potential of Compounds Bearing Thiazolidin-4-one Scaffold: Comprehensive Review Download PDF

Dalbir Singh , Mona Piplani , Harsha Kharkwal , Sankaranarayanan Murugesan , Yogendra Singh , Amit Aggarwal , Subhash Chander
Abstract
Thiazolidin-4-ones is a versatile and privileged nucleus comprising of a five five-membered heterocyclic ring system possessing sulphur heteroatom and a cyclic amide bond. Extensive research and review studies mainly published in the last decade explored the diverse types of biological activities of this nucleus with potential therapeutic applications. Various silent features like drug likeness behaviour, suitability for diversity-oriented synthesis, and its sensitivity toward the redox tumour microenvironment makes it an attractive scaffold for anti-cancer drug discovery. Thiazolidine-2,4-dione and thiazolidine-4-ones are the two classical variants of thiazolidine scaffold, the former is more explored in comparison to thiazolidine-4-one. However, thiazolidine-4-one nucleus is also getting the attention of researchers, evident by the various research studies, mainly published in the last few years.
The current comprehensive review focuses on its anti-cancer potential, covering structural diversity and substitution patterns among diverse derivatives containing this nucleus as a core skeleton. This review also gives impetus to the different enzymatic targets, exploited for drug discovery, relative selectivity in cancerous tissue compared to healthy counterpart cells, structure-activity relationship (SAR), and future perspectives for translational research. To generate potential lead candidates with the translational outcome next level studies like pharmacokinetic and metabolic stability are suggested.
Cite this article
Vancouver
Singh D, Piplani M, Kharkwal H, Murugesan S, Singh Y, Aggarwal A, et al. Anticancer Potential of Compounds Bearing Thiazolidin-4-one Scaffold: Comprehensive Review. Pharmacophore. 2023;14(1):56-70. https://doi.org/10.51847/oHzuia1yg6
APA
Singh, D., Piplani, M., Kharkwal, H., Murugesan, S., Singh, Y., Aggarwal, A., & Chander, S. (2023). Anticancer Potential of Compounds Bearing Thiazolidin-4-one Scaffold: Comprehensive Review. Pharmacophore, 14(1), 56-70. https://doi.org/10.51847/oHzuia1yg6
EndNote RIS XML
Full HTML
QR code:

Short Link:
Views: 2054
Downloads: 329
Quick Access
Author Guidelines
Copyright Form
Manuscript Submission
Joining Editorial Board
Joining Reviewers Team
Associations
Pharmacophore
ISSN: 2229-5402
Subscribe to updates
Contact Us
Copyright © 2024 Pharmacophore. Authors retain copyright of their article if they are accepted for publication.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.