The aim of the present study was to investigate anticonvulsant effect of ethanolic extract of Picrorhiza kurroa on electrically and chemically induced seizures. The ethanolic extract of the roots of Picrorhiza kurroa was studied for its anticonvulsant effect on maximal electroshock-induced seizures and pentylenetetrazole, picrotoxin induced seizures in mice. The latency of tonic convulsions and the number of animals protected from tonic convulsions were observed. It has been observed in the present study that SPK (100 mg/kg) showed significant increase in latency to clonic convulsions and reduced mortality, however SPK (25 and 50 mg/kg) failed to show anticonvulsant activity against PTZ induced convulsions in mice. Further animals treated with SPK (25, 50 and 100 mg/kg) did not show any significant effect on the latency to THLE in MES induced convulsion. Thus we can conclude that Picrorhiza kurroa possess anticonvulsant activity against Pentylenetetrazole (PTZ), Maximal electroshock (M.E.S.) and Picrotoxin (PTX) induced convulsions in mice.