Aspergillus species cause a wide range of diseases including allergic syndromes, chronic pulmonary and nasal sinus aspergillosis and acute and sub acute invasive disease. Resistance of Aspergilli to some clinically used antifungal brings a worrying clinical prognostic in people attacked by aspergillosis. The number of fundamentally different types of antifungal agents that are available for treatment remains extremely limited. Currently there are four classes of antifungal agents with activity against Aspergillus. Resistance in Aspergillus is emerging but the data on the antifungal compounds are limited compared to other fungal species. In this paper summarized some known antifungal drugs against diseased causing Aspergillus species.