Pharmacophore an International Research Journal
Age-related, pathogenic, and traumatic alterations in the major superficial vein following its isolation by an open technique before the creation of an anastomosis were investigated using ultrasound Dopplerography and morphological analysis. It is demonstrated that in multiple observations, the lumen enlarges and the value of the elasticity index moderately declines. Age-related changes in the wall of the great saphenous vein were characterized by coarsening of connective tissue structures in the subendothelial layer of the inner shell, which in places had thickening with the replacement of elastic fibers with collagen. Pathological alterations that were evaluated morphologically included sclerosis, hypertrophy, and, occasionally, indications of atrophy and elastolysis. When a vein is isolated due to its injury, edema, desquamation of the endothelium, and hemorrhages occur in the endothelial layer and subendothelium, which may play a role in future graft stenosis. The analysis of long-term results was carried out based on clinical examination data and ultrasound Dopplerography. The five–year patency of shunts was 64%, and the seven-year patency was 43%.
