Epistaxis, one of the most common Otolaryngology emergencies, refers to bleeding from the nose, nasal cavity, or nasopharynx. 90%–95% of nosebleeds can be managed using first-aid procedures like tilting the patient's head forward and applying digital compression to the nasal alae and anterior septal area. Epistaxis is typically a benign, self-limiting, spontaneous disorder that can be treated at home. The aim of this study to evaluate the knowledge, and practice of the Saudi population regarding the first aid management of epistaxis. A Cross-sectional study was conducted in KSA, including both adult males and females, who participated in a pre-validated questionnaire that consisted of 22 questions on the knowledge and practice assessment. The study included 1750 participants, 52.7% of them were females and 47.3% were males. 78.8% of the respondents reported experiencing epistaxis. A significant portion of individuals possess only poor knowledge, accounting for 26.9% of the total. On the other hand, those with moderate knowledge make up 48.3%, indicating a larger proportion of individuals falling into this category. Lastly, individuals with good knowledge represent 24.8% of the population. As for practice, 64.9% of participants had poor practice, 32.6% had moderate practice, and 2.5% had good practice score. In conclusion, the study shows low knowledge and practice levels from the Saudi population towards first aid of epistaxis. Results show statistically significant associations between knowledge scores and factors such as age, gender, nationality, location, education level, and occupation. Practice scores were only significantly associated with the age and occupation of participants.