Association between reperfusion time, CTFC and inflammatory biomarkers in STEMI patients Download PDF

Objective: We investigated inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), CTFC and time to intervention in myocardial infarction with persistent ST-segment elevation (STEMI) undergoing primary angioplasty. Patients and Method: A cohort of 104 consecutive patients with STEMI undergoing primary PCI was enrolled. Relationship between patients ESR and CRP at the time of admission and CTFC and pain duration was evaluated. Results:Our data showed that the higher ESR and CRP the more CTFC. In our study there no correlation was detected between CTFC and ESR and CRP after intervention (p= no significant). In our study mean±SD for CTFC measures according to pain duration before PPCI (less than 2 compared with more than 6 hours) were defined as 20.17±2.22 and 31.84±5.84, respectively. Increasing time before reperfusion was associated with higher CTFC values (p=0.001) . Conclusion:Elevated ESR and CRP at the time of admission are associated with higher CTFC values in STEMI patients treated with reperfusion therapy.Lower time to reperfusion has important role in reducing ESR and CRP at the time of admission and CTFC values that can improve patients’ survival with AMI undergoing PPCI.