A new variant of the Coronaviridae family is the main reason for the contagious Coronavirus disease (COVID-19). COVID-19 mainly spreads by direct contact with the virus through contact with a COVID-19's patient, coughing, sneezing, or touching surfaces contaminated with the virus. The Ministry of Health (MOH) has made the audience conscious of the virus infectious styles and the value of quarantine, curfew and vaccination versus COVID-19. Despite strict measures taken, the awareness of people towards vaccination against COVID-19 and symptoms of the vaccination against COVID-19 the most important factor in limiting the widespread of diseases. To assess the awareness of risk the perceptions attitude about signs and Symptoms of the Vaccination against COVID-19 and communication practices of Vaccination about COVID-19 among the Adult Saudi Population. This cross-sectional study was conducted online among Saudi Arabia adults population in a primary health care center in Makkah Al-Mukarramah. The questionnaire collected socio-demographic characteristics, attitudes about symptoms of the vaccination against COVID-19, and practices of vaccination about COVID-19. A self-managed survey was proposed and has been sent to the study entrants during social media platforms and email. Our total entrants were (350). During the pandemic interval, a strong request for and high acceptance of COVID-19 inoculation has been cleared among the Saudi Arabia population, many adults are willing to get a COVID-19 vaccine, though acceptability should be monitored as vaccine development continues, while concerns exist about symptoms of vaccination against COVID-19. To expand vaccination coverage, programs should be designed about symptoms.