For wounds, discomfort, infection, and healing, there are a limited number of medications used in oral and maxillofacial surgery. Despite their widespread use, little is known about these medications' components, applications, and effects on oral tissues. Whitehead's varnish (WV), Carnoy's solution (CS), Bismuth Iodoform Paraffin paste (BIPP), Zinc Oxide Eugenol (ZOE), Alvogyl are some of the substances that can be used effectively. A systematic literature review from 2012 to 2022 will be performed using databases such as PubMed, Medline, and Sciencedirect. The keywords used will be “BIPP”, “ZOE”, “Alvogyl” and “intraoral wound dressing”. PRISMA flowchart will be used to describe the selection process of searched articles. Mixed findings have been observed especially when choosing between ZOE and Alvogyl as an intraoral wound dressing material. Each of these two materials possesses suitable qualities. However, BIPP has not been witnessed to be used frequently due to its potential for side effects when used for longer durations. Alvogyl and Zinc Oxide Eugenol are equally acceptable materials of choice for use as intraoral dressing.