Parisa Alibek1, Seyed Ali Asghar Moshtaghi2, Seyed Hossein Hejazi3
Regarding the prevalence of taking naproxen, mefenamic acid and paracetamol, the effects of these drugs on liver enzymes and comparing the effects of doses and the length of treatment, help to prevent liver damage, to the extent possible and to choose the least harmful treatment NSAIDs.
The aim of this study was to compare the effects of naproxen, mefenamic acid and paracetamol on serum levels of liver enzymes in Wistar rats. In this study, a comparison of the effect of naproxen with different doses of 40 and 10 mg / kg body weight, mefenamic acid at doses of 400 and 100 mg / kg body weight and paracetamol at doses of 60 and 15 mg / kg body weight in two periods Short-term and long-term effects on liver enzymes.
Data were compared using spss software. To evaluate the results, p <0.05 was considered as the significant level of differences.
Based on the results obtained from the Duncan test and paired t-test, liver enzymes activity was significantly increased in most treatment groups compared to control, but did not show significant increase in naproxen treated groups. An increase in the alkaline phosphatase enzyme is due to its hepatic isozymes increase.
The results suggest that mefenamic acid with low doses and then high-dose paracetamol in the short-term have the highest elevations of liver enzymes, which can be due to damage to liver cells or liver metabolism. In addition, naproxen has the least harmful effect on the liver and has the least change in liver enzymes compared with the control group.
