Comparing miRNA-224 Expression as a Biomarker to Discriminate Diseases in Serum Chronic Hepatitis B and HBV- Related Cirrhosis Download PDF

Hepatitis B virus (HBV) is a partially double-stranded circular DNA genome with a high tendency to liver tissue. Chronic hepatitis B varies from an asymptomatic infection to symptomatic chronic hepatitis, cirrhosis and hepatocellular carcinoma. In this study, serum miR-224 expression in healthy people, chronic hepatitis B and cirrhosis caused by hepatitis B was compared. The indices achieved were 35.13, 35.51 and 36.29, respectively. Difference in miR-224 expression level of patients with cirrhotic hepatitis B was significant, but it was not significant in people infected with hepatitis B. However, the significant difference between people with cirrhosis and hepatitis B infection is a measure to determine the developing from chronic to cirrhotic state which can be a valuable criterion for the diagnosis of disease in people infected with hepatitis B.