A Simple precise and accurate method was developed and validated for the simultaneous analysis of chlorthalidone and irbesarton in tablet formulations. The method has been shown adequate separation of the two ingredients from each other. The chromatographic separation was achieved on a reverse phase column C18 (250 mm x 4.6 mm, 5μ), in a mobile phase consisting of 0.02 M ammonium phosphate buffer (adjusted to pH 5.5 with triethyl amine), acetonitrile and methanol in the ratio (40:40:20, v/v/v) at a flow rate of 1 ml/min with UV detection at 220 nm. This new method was validated, which include assay determination, accuracy, precision, selectivity, linearity and range, robustness and ruggedness. The current method demonstrates good linearity over range of 40-60% μg/ml of chlorthalidone with r2 =0.9991 and in the range of 480 - 720 % μg/ml of irbesarton with r2 = 0.9990. The average recovery of the method is 99.22 % μg/ml and 102.28 % μg/ml for chlorthalidone and irbesarton, respectively. The degree of reproducibility of the results obtained as a result of small deliberate variations in the method parameters and by changing analytical operator indicating that the method was found to be sufficiently robust and rugged. A simple, accurate, precise RP-HPLC method was developed and validated for the simultaneous determination of chlorthalidone and irbesarton in tablet formulation.