Effect of Maternal Supplementation with 200 And 50,000 IU Vitamin D on Serum 25 (OH) D Levels of Pregnant Women Download PDF

Background and Objectives: Vitamin D deficiency during pregnancy lead to adverse outcomes for both the mother and fetus. This study aimed to compare the impact of vitamin D supplementation (200 and 50,000 IU) on serum 25-hydroxyvitamin D levels in pregnant women. Methods: This randomized clinical trial was conducted on 90 pregnant women with gestational age of 12-16 weeks at Sayyad Shirazi Hospital, Gorgan (northern Iran), during 2013-2014. Pregnant women were randomly divided into two equal groups. Group A received 200 IU of oral vitamin D and Group B received 50,000 IU of oral vitamin D daily for eight weeks. Results: After the intervention, serum vitamin D level was 15.17±7.40 ng/dL in group A and 18.85±6.52 ng/dL in group B. After the intervention, Vitamin D levels differed significantly between the two groups (P<0.01). The incidence of gestational diabetes mellitus was significantly higher in group A compared to group B (P<0.006). Conclusion: Supplementation with 50,000 IU of vitamin D significantly increases serum vitamin D3 levels in pregnant women.