Effect of Oral Dydrogesterone Compared with Progesterone Suppository for Luteal Phase Support in Cycles of Frozen Embryo Transfer Download PDF

Background:Dydrogesterone is an analog of oral progesterone, which can reduce the side effects of vaginal progesterone and has advantages such as greater tolerance to luteal phase support (LPS). In this connection the limited studies available and needs more study. the aim of this study was to evaluate the protective effect of this drug on LPS after frozen embryo transfer in IVF cycle. Methods:In this trial, 200 women with infertility and IVF candidate again, divided in two equal one hundred groups that include: consumers of progesterone (intravaginal, 800 mg daily) and oral Dydrogesterone (20 mg daily) for luteal phase support groups. The frozen embryos from IVF are transferred to the uterus and implantation rate, clinical pregnancy (CPR), ongoing pregnancy (OPR) and abortion were compared. Results:Respectively,the mean age of patients in intravaginal and Dydrogesterone was 5.2 ± 33.5 and 5.1 ± 32.9 years (p = 0.2) and the mean duration of infertility was 2.8 ± 5.6 and 2.5 ± 6 years (p = 0.7). Implantation rate was 8.9% and 7.3% (p = 0.6), average CPR was (20 patients) and 20% (n = 18) 18% (p = 0.04). Average OPR after 3 months of embryo transfer was 18% (n = 18) and 9% (n = 9) (p = 0.09). Among pregnant women after three months of pregnancy the rate of aborton was 18.1 and 37.7% (4 nd5 patients) (p = 0.4), respectively, in the intravaginal and Dydrogesterone groups. Conclusions:In this small study the intravaginal regimen compared to Dydrogesterone was associated with higher CRP significantly and implantation, OPR and abortion rate, had not significant difference between two groups. The intravaginal progesterone against orally Dydrogesterone for LPS after IVF may be the superior choice.