Effects of Crocin and Resistance Training on Liver Enzymes in Toxicated Male Rats by Nandrolone Decanoate Download PDF

Introduction: The purpose of this study was to investigate the effects of crocin and resistance training on liver enzymes in toxicated male rats by Nandrolone decanoate. Method & materials: Fifty six male Wistar rats (age: 9 weeks, weight: 190±10g) were randomly divided into eight groups: control group (Co, n=7), sham group (Sh), 10 mg/kg of Nandrolone decanoate group (Nd), resistance training group (RT), 12.5 mg/kg of crocin group (C1), 25 mg/kg of crocin group (C2), RT and 12.5 mg/kg of crocin group (RT-C1) , RT and 25 mg/kg of crocin group (RT-C2).All the groups were injected by Nandrolone decanoate (10mlg/kg of body) except (Co and Sh)groups. Resistance training was progressively and consisted of climbing the ladder and started with carrying a load of 50% of body weight. Twenty four hours after the last injection, the animals were sacrificed. Blood samples were obtained from left ventricle immediately and analyzed for liver enzymes (AST, ALT, ALP and GGT), albumin, total protein. Testicular and liver were brought out of their body for analyzing. Data were analyzed using two way analysis of variance. Results: Data analysis revealed that the interaction effect of crocin and resistance training cause to significant changes on ALT, GGT, Albumin and Total protein (P<0.05). The main effect of crocin on albumin and total protein were significant (P<0.05). Also, there were not any significant changes on AST and ALP (P>0.05). Conclusion: In general, resistance training and crocin consumption result in eliminate or improve of complication of Nandrolone decanoate in liver organ.