Sudden cardiac death represents a significant global health issue. Despite advanced resuscitation procedures, post-cardiac arrest consequences, especially neurological outcomes, remain a health burden. Several methods were conducted to improve survival rate and prevent post-arrest neurological outcomes, including therapeutic hypothermia. This narrative review aims to assess the latest update on therapeutic hypothermia effect in post-cardiac arrest syndrome, either out-of-hospital arrest or inside-hospital arrest. We tried to summarize the impact of therapeutic hypothermia in both shockable and non-shockable rhythms. A 20 references were searched in the PubMed database using relevant Mesh words: Therapeutic hypothermia, Cardiac arrest, Resuscitation, post-cardiac arrest syndrome. Therapeutic hypothermia with targeted temperature measurement (32° to 36°C) has beneficial effects in post-cardiac arrest patients. The better outcomes were reported in patients with shockable rhythm upon presentation and/or out-of-hospital arrest. The other non-shockable rhythm and in-side hospital arrest conditions require further clinical trials to establish therapeutic hypothermia efficacy and safety among these groups. Overall, therapeutic hypothermia provides a safe profile with controllable side effects in the intensive care setting.