Evaluating the impact of lithium carbonate nanoparticles on the activity of the pituitary-gonad hormone and liver transaminases in the neonatal period in adult female rats Download PDF

Infertility is considered as one of the most common problems in human communities. It is defined as lack of incidence of the pregnancy after one year of regular sexual intercourse and without using contraceptive methods. In addition, liver diseases are among the most common diseases in the community. As a result, many diseases, bad nutritional statuses, obesity or overweight, low mobility, consumption of alcoholic drinks, and taking some drugs are caused. The current research was conducted to examine the impact of lithium carbonate nanoparticles on pituitary-gonad activity and liver in female rats (Wistar race). In this research, 40 female rats (Wistar race) at weight range of 200-180 g were used as parent. All parent samples were randomly divided into four groups (each group containing ten rats), including control, placebo, experimental, 1 and 2 groups after the delivery. Control group received no treatment, and the placebo group received 0.5 cc of normal saline in daily basis during the breast-feeding period, and two experimental groups 1 and 2 received the values of 1.26 mg / kg of the rat weight and 1.90 mg / kg of the rat weight of lithium carbonate nanoparticles, respectively, intraperitoneally daily during breast-feeding. At the end of experiments lasted for 24 days, blood samples were taken from the heart of the female neonates (n=10 in each group). After separating the serum, concentration of the hormones estrogen, progesterone, FSH and LH, and the enzymes AST, ALT and ALP was measured and ovarian and liver tissues were separated. Then, histologic stages of slides were prepared and evaluated in terms of histology. Findings indicated that lithium carbonate nanoparticles caused significant reduction in the values of FSH, LH, estrogen and progesterone hormones and the number of primordial, pre-enteral, and antral follicles, and yellow objects and hepatocytes, and it caused significant increase in liver enzymes and atrophy follicles (P <0.05). Given the characteristics of the lithium carbonate nanoparticles, it is supposed that lithium carbonate nanoparticles destruct the sexual cells, leading into reduced sexual hormones and increased liver enzymes.