Pharmacophore an International Research Journal
Some drugs are bitter and unpleasant in taste and taking orally very difficult for children and some adults. Non‐compliance can lead to worsening of diseased condition. Numbers of taste masking technologies have been used to address the problem of patient compliance. The purpose of this research was to mask the intensely bitter taste of Ofloxacin and to formulate a palatable liquid formulation of the taste-masked drug, by novel Ion Exchange Resin (IER) method to overcome taste problem with traditional system. Taste masking was done by complexing Ciprofloxacin HCl with Tulsion 339, Tulsion 344 and Indion 254 in different ratios. Formulation containing resinates were tested for drug content, in vitro drug release, taste masking, stability study, and molecular property. The resinates prepared with drug-Tulsion 344 ratio (1:2) at pH 8, gave maximum drug loading. Suspension containing above resinates showed more than 80% in vitro drug release within 30 min. Prepared formulation also showed good stability and can retain its palatable taste. Thus, the “patient-friendly dosage form” of bitter drugs, especially for pediatric, geriatric, bedridden, and non-cooperative patients, can be successfully formulated using this technology.
