This study was conducted in order to investigation of different cadmium and lead concentrations on agronomic traits and essential oil content at Ferdowsi University of Mashhad, Iran in 2017. The experiment was conducted as factorial based on the randomized complete block design with three replications. The first factor was cadmium concentrations( 0, 10, 20 and 40 ppm) and the second factor was lead concentrations( 0, 100, 300 and 600 ppm). Sage plantlets were transplanted at 2 leaves stage. The results indicated that effect of cadmium and lead on fresh weight, dry weight, plant height, essential oil content, cadmium and lead absorption by roots and shoots had significant differences. Fresh weight of shoots at 40 ppm of cadmium and 600 ppm of lead concentrations were declined 4.61% and 5.16%, respectively as compared as control. Dry weights of shoots at the highest concentrations of cadmium and lead were decreased 10.83% and 11.08% as compared as the control. The highest absorption of cadmium by shoots was observed at 40 ppm and 600 ppm of cadmium and lead concentrations, respectively. In this research cadmium and lead were not detected in essential oil. Accordingly, it seems the sage could considered for cultivation under using the contaminated waters by cadmium and lead.