Evaluation of the serum level of antioxidants in patients with brain tumor Download PDF

Background: Intracranial neoplasm is one of the major health problems in both industrialized and developing countries. As in other chronic diseases, several factors, including reactive oxygen species, are involved in its development. The role of antioxidants in the development of brain tumors has been the subject of researches for many years. Their main effects are on pro-oxidants produced by normal cell metabolism processes. Vitamin C, ferritin, and ceruloplasmin are considered the most important antioxidants in the body. Methods: serum level of Vitamin C, ferritin, and ceruloplasmin of 102 people (patients = 51; controls = 51) were measured, using enzyme-linked immunosorbent assay (ELISA), and compared afterwards. Results: Serum ferritin level was significantly associated with the risk of intracranial neoplasm. The same applies to the serum level of vitamin C, although to a lesser extent. On the other hand, there was no significant relationship between serum ceruloplasmin level and brain tumor. Conclusions: Various studies have reported different results with regard to the relationship between antioxidants and intracranial neoplasm. The impact of these materials on refining of pro-oxidants in different body tissues could be an appropriate ground for reducing the risk of chronic diseases including tumors.