Introduction: Farming has been rated as an extensive and dangerous occupational activity that requires tolerating inappropriate physical condition. This study investigated the prevalence of musculoskeletal disorders and their related factors among farmers of Asadabad city in 2015. Materials and Methods: This descriptive-analytical and cross-sectional study was conducted on 378 male farmers in Asadabad city of Hamadan. A nordic standard questionnaire was used for data collection in this research which was completed by trained personnel and was analyzed statistically. Findings: The musculoskeletal disorders prevalence rate of farmers was 6.9% in the neck, 6.6% in shoulders, 1.1% in the elbow, 4.5% in the wrist, 6.1% in the back, 19% in the waist, 10.1% in the hip and thigh, 2.1% in the knee and 5% in the leg. Based on the obtained results, there was a significant relationship between the prevalence of musculoskeletal disorders in the leg area with age and between the prevalence of musculoskeletal disorders in the back area and farmers' awareness level. There was a significant relationship between the prevalence of musculoskeletal disorders in the neck, shoulder, back and waist areas with the history of the disease (P<0.05). There was also a significant relationship between the prevalence of these disorders in the neck, shoulder, back, waist, knee, and leg with a history of occupational accidents (P<0.05). Conclusion: Ergonomic interventions, designing tools and performing exercise movements at defined time intervals and promoting farmers' level of knowledge in the form of educational programs of occupational health are recommended.