Introduction: There are different methods such as Sclerotherapy, open surgery, and laparoscopy for the treatment of kidney cysts. The aim of this study is to examine the frequency of endoscopic resection operation in the treatment of large symptomatic simple renal cysts and its complications in Jahrom. Method: This descriptive study was conducted on patients with symptomatic renal cysts larger than 5 cm who referred to Peymanieh Hospital of Jahrom from 2007 to 2009. These patients underwent percutaneous endoscopic resection of cysts. The questionnaire was completed for all patients. Data were analyzed at descriptive and inferential statistics levels using SPSS. Results: 100 patients with an average age of 57.07±7.67 participated in this study. Pleural and intestinal perforation, rupture of the spleen and liver and severe kidney damage were not seen in any patient. Five percent of patients had leakage of urine, 7% prolonged hematuria, 5% urinary tract infection, and 1% had infection of stitches. Hematoma was formed in the operational place about 9% of patients. Sixteen percent of patients suffered a minor pain after surgery and 53% com-plained of moderate pain. The average loss of hemoglobin compared with pre-operation stage was 1.95±0.57 mg/dl. With increase in patients' age, size and number of cysts also increased. Thus, they were prone to formation of hematoma, drop in hemoglobin and long-lasting hematu-ria. Conclusion: Our studies showed that percutaneous endoscopic resection of kidney cysts is a safe and effective method with minimal invasion and the rate of morbidity and recurrence after operation is low.