Expression of Hsa-miR-186 In Human Colon Cancer Download PDF

Objective: Increasing evidence has shown that microRNAs function as oncogenes or tumor suppressors in human malignancies ,here we explore the expression of hsa-miR-186 in human colorectal cancer tissues. Materials and Methods: In this experimental study, the expression of hsa-miR-186 in colon cancer tissue and the adjacent tissues in 15 paired were analyzed using real-time quantitative RT-PCR. Results: The relative expression of miR-186 in the cancer tissues was significantly lower than that in the adjacent tissues (about 9 fold, P=0.008). Conclusion: As a tumor suppressor gene, hsa-miR-186 is down-regulated in human colon carcinoma tissues and compared with adjasent tissues.