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Open Access | Published: 2016 - Issue 2

FIRST DERIVATIVE SPECTROPHOTOMETRIC SIMULTANEOUS DETERMINATION OF VILDAGLIPTIN AND METFORMIN IN TABLET FORMULATIONS Download PDF


Karajgi Santosh Raveendra, Shahid Momin Gaffar and Navanath V. Kalyane
Abstract

A simple, accurate, precise and reproducible method has been developed for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in combined tablet dosage forms. Vildagliptin has absorbance maxima at 218.25 nm in water and Metformin Hydrochloride has absorbance maxima at 225.5 nm in water. Both these drugs obey Beer’s law in concentration range of 60-100 μg/ml (Vildagliptin) and 10-50 μg/ml (Metformin Hydrochloride) with mean recovery 100% for both drugs Vildagliptin and Metformin hydrochloride respectively. The results of the analysis were validated statistically and recovery studies were carried out as per ICH guide lines. Thus the proposed method can be successfully applied for the simultaneous estimation of Vildagliptin and Metformin hydrochloride in routine analysis work.

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Pharmacophore
ISSN: 2229-5402


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