Background: Gastroesophageal reflux disease is one of the most common complaints in the medical field. Increased acid production and relaxation of the lower esophageal sphincter are considered the most common causes of this disease. Patients could present with epigastric pain that can be radiated to the left shoulder and can lead to a similar presentation of cardiac disease. Treatment could be non-pharmacological like weight loss and lifestyle modifications or pharmacological like given PPI other medications or surgical for refractory cases. Objective: The objective of this review is to discuss Gastro-esophageal reflux disease, different presentations, and management plans with great details. Method: We searched the PubMed database looking for relevant articles to the topic using Mesh terms, “Gastro-esophageal reflux disease". Conclusion: Gastro-esophageal reflux disease is a common condition, the early diagnosis, and treatment, will not only treat your patient, and rather, it will prevent serious complications like malignancy.