Pharmacophore an International Research Journal
The goal of the current study is to design a chronomodulated medicine delivery system for nocturnal acid situations. This strategy is based on a combination of floating and pulsatile principles. With this idea in mind, a floating-pulsatile drug delivery system of lafutidine was created to lengthen the time the dosage form, which has a lag phase followed by a burst release of the drug, stays in the stomach. Accordingly, floating pulsatile tablets were developed in three different steps viz. Preparation of drug-containing core tablets using a super disintegrant, pulsatile layer by compression coating using a mixture of hydrophilic erodible polymers like HPMC E5M and guar gum; and buoyant layer using gel-forming polymer like Carbopol 934P with sodium bicarbonate and citric acid. The effects of the independent variables—the weight ratio of HPMC E5M: Guar gum and the total weight of coating—on the dependent variables, the drug release lag time and cumulative percent drug release at 6 h, were studied using the response surface approach. Developed formulations were evaluated for buoyancy, dissolution, and stability studies. Results indicated the dependence of lag time on the ruptured nature of polymers used. Drug release lag time of optimized batch was found to be 6.20 ± 0.35 h with 98.45 ± 2.24 % of drug release at the end of 8 h. Accelerated stability studies suggested stability of dosage form for at least one month. In order to achieve the best treatment efficacy and increase patient compliance, a successful, stable, floating, pulsatile tablet was created. It can be administered after dinner at around 22:00 h.
