Herbal drugs of abuse are being practiced for ages. Old-fashioned addictive substances, such as opium, and cannabis are mainly imitated or altered from the ingredients likely based on crude drugs. Cannabinoids and cathinone are derived from natural derivatives. Safety and efficacy altogether is a matter of concern that needs to be discussed and awareness related to that must be spread. In this review, we briefly, discuss some plants such as khat, kratom, salvia, and mandrake, with the perception that experts and common people alike are aware of the possible glitches caused by regular and synthetic derivatives, and appropriate resistor procedures will be taken. Some "herbal plants" should be termed as injurious drugs since chronic management has been connected with addiction and cognitive deficiency, and findings inspecting these features are deficient. This paper discusses toxicity issues and main safety concerns regarding plant-derived products. Safety persists as the major concern with the use of herbal remedies, it becomes imperious, to ensure that all herbal constituents are safe and reliable.