Human papillomavirus (HPV) is the most common causative agent of cervical cancer, national and international decisions are made regarding HPV vaccines and the prevention of cervical cancer. Risk-benefit assessments and critical data analyses are significant for reaching consensus. Much controversy is still present over whether the benefits of the available 'HPV' vaccines outweigh its risks. It has reduced the acceptance of the 'HPV' vaccines compared to other various vaccines. Concerns regarding the safety of the 'HPV' vaccines have resulted in many physicians/healthcare providers and parents refusing the HPV vaccine. The most typical cause for not taking the prophylactic HPV vaccine was concerns regarding it is side effects. However; It is recommended that a different independent system for monitoring vaccines immunogenicity as well as side effects is established for addressing possible conflicts of interest via qualified professionals to accurately assess the side effects related to HPV vaccines. Eventually, it is recommended that expanded usage of HPV vaccines to further various populations, especially those who live within poor settings, may provide various health benefits using preventing HPV-related diseases. This review aims to assess the scientific peer-reviewed data associated with assessable outcomes from the usage of 'HPV' vaccines worldwide with more attention on the possible side effects.