Phytotherapy today avails itself of the extensive knowledge on its active principles and its chemical and pharmacological characteristics. It seemed, therefore, reasonable and timely to assess the validity of phytotherapeutic products in the adjuvant treatment of hyperlipidemia. Papaya (Carica papaya linn) is well known for its exceptional nutritional and medicinal properties throughout the world. From the times immemorial, the whole Papaya plant including its leaves, seeds, ripe and unripe fruits and their juice is used as traditional medicine. Cow is a mobile dispensary. It is the treasure of medicines. The cow urine therapy is capable of curing several curable and incurable diseases. Present work aim to check potency of cow urine with freshly prepared hydroalcoholic extract of Carica papaya leaf preparation with potent anti-hyperlipidemic activity. The results of study reveal that the juice and hydroalcoholic extract of Carica papaya with CU when administered to the obese & hyperlipidemic rats causes significant decrease in the body weight, Serum TC, LDL, TG and VLDL level.