Some common medicinal plants that are used either alone or in association, and sold as industrial preparations or by phytotherapists for the treatment of hyperlipidemia. We used two medicinal plants namely Lagenaria siceraria and Carica papaya with cow urine for the treatment of Hyperlipidemia. Hyperlipidemia is a condition of excess fatty substances called lipids, largely cholesterol and triglycerides in the blood. It is also called hyperlipoproteinemia because these excess lipids travel in the blood attached to proteins. The aim of present study is to evaluate and compare the anti-hyperlipidemia effects of cow urine & freshly prepared juice and hydroalcholic extract of Lageraria siceraria fruit & Carica papaya leaf in high fat diet induced hyperlipidemia rat with marketed Atorvastatin. Present work aim to check potency of cow urine with freshly prepared juice and hydroalcholic extract of Lageraria siceraria fruit & Carica papaya leaf preparation with potent anti-hyperlipidemic activity. In present study four preparations were taken i.e. Lagenaria siceraria fruit juice (LSFJ) and Carica papaya leaves juice(CPLJ) with CU in dose of 10 ml/kg and 20 ml/kg and hydroalcoholic extract of Lagenaria siceraria (LSFE) and Carica papaya leaves extract(CPLE) with CU in dose of 100 mg/kg and 200 mg/kg. LSFJ and CPLJ in dose of 20 ml/kg and LSFE and CPLE in dose of 200 mg/kg showed the most significant results among other preparation in high fat diet induce obese and hyperlipidemic rats. The results of study reveal that the juice and hydroalcoholic extract of Lagenaria siceraria and Carica papaya leaves with CU when administered to the obese & hyperlipidemic rats causes significant decrease in the body weight, Serum TC, LDL, TG and VLDL level.