Pharmacophore an International Research Journal
The study aimed to evaluation of immunohistochemical the Euphorbia Inarticulata Extract on Liver and Kidney Tissues in Hepatocellular Carcinoma Rats. Rats were grouped into six each of six as (1) control received one dose (1 ml 0.9% NaCl/ip) and two weeksafter 2 weeks later receivedgot olive oil (1 ml/sc) (once/week) for 16 weeks, in line with 1% DMSO/p.o. for 18 weeks. (2) 250mg Extract and (3) 400mg Extract groups were received as in the control group and received daily extract (250 mg/kg/P.o.) and (400 mg/kg/P.o.) in DMSO for 18 weeks, respectively. (4) DENA/CCl4 group received one dose of DENA (200 mg/kg/ip) in saline and two after 2 weeksweeks later received (3 ml/kg CCl4/sc) in olive oil (once/week) for 16 sixteen weeks, in line with 1% DMSO/p.o. for 18 weeks. DENA/CCl4 rat model group showed an induced strong positive reaction to Bax immunostaining in the cytoplasm of liver cells and glomeruli and renal tubules. The study suggests that the present model showed hepatic and renal apoptosis that is related to impairing their function and oral administration of E. inarticulata methanol extract, especially in higher dose (400 mg).
