Plants that contain medicinal properties are defined as everything of plant origin, containing one or more medicinal substances capable of treating or reducing a specific disease, or containing raw materials used in the preparation of medicinal substances. Plants that contain medicinal properties can be made more effective in medicine and therapy, so we worked on this investigation to evaluate the immunological and histological effects of pomegranate fruits (POF) and peel (POP) in hepatotoxicity in rats. The investigation was carried out on a caged animal. All rats were kept on a basal diet for one week prior to the study, and they were separated into seven groups, of six rats each. As control negative normal rats (C–ve), the first group sample was fed only the basal diet for 28 days. The remaining rats (n=36) were injected with carbon tetrachloride (Ccl4). Five groups were fed varying concentrations of (5%, 10%, 15% POF, 5%, and 10% pomegranate peel (POP)), whereas one group was diagnosed with the illness and disease, and didn't even feed the experimental diet. The results discovered non-significant variances in Phagocytosis between (C –ve) normal rats and Ccl4-intoxicated rats then fed on 5% and 10% POP Also, found non-significant differences in killing percent between rats injured by Ccl4 then fed on formulas 5%,10%, and 15% POF.