Pharmacophore an International Research Journal
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Open Access | Published: 2016 - Issue 6

In-Vitro Anti Diabetic Efficacy (Potential) Of Leaf Ethanol Extract Fractionates Of Pisonia Grandis R.Br Download PDF


P.Lalitha, Janathul Firdhouse and Shubashini K.Sripathi
Abstract

In this study, the anti diabetic potential of column fractions of leaf ethanol extract of P.grandis was assessed by α-amylase inhibition assay. Acarbose (250μg/mL) used as a standard for reference showed 67% inhibition efficiency . The results of the study disclose the amylase inhibition potential of all fractions of P.grandis which can be correlated to anti diabetic potential. The isolated molecule pinitol (250 μg/mL ), the fraction PGL aq.1 obtained by liquid-liquid extraction of P.grandis leaves and the column fractionate PGL1% (both at a concentration of 20 μg/mL ) exhibited the highest inhibition of α-amylase. All other fractionates (at concentration of 20 μg/mL) also exhibited moderate inhibition of α-amylase. The promising use of P.grandis extracts in formulating anti diabetic agents is obvious from the results.

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Pharmacophore
ISSN: 2229-5402


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