Pharmacophore an International Research Journal
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Open Access | Published: 2019 - Issue 3

In Vitro Study of The Antimicrobial Effect of Synthesized Copolymer Compounds ‎Against Staphylococcus Aureus and Escherichia Coli Strains Download PDF


EL Korso Fatiha Narimene, Sebba Fatima Zohra, Rechache Mustapha
Abstract

The newly synthesized antimicrobial copolymers i.e. [poly N-vinylpyrrolidone -block- poly ε-caprolactone -ɷ-hydroxyethylmethacrylate] (KFB), [(poly N-vinylpyrrolidone -block- poly ε-caprolactone -ɷ-hydroxyethylmethacrylate) -graft- poly-4-Vinylpyridine] (KFC)  and   [(poly N-vinylpyrrolidone -block- poly ε-caprolactone -ɷ-hydroxyethylmethacrylate) -graft- poly-4-Vinylpyridine octyl bromide] (KFCQ), were tested in vitro, using diffusion disc method (MDD) against two microbial strains: gram-positive bacteria Staphylococcus aureus ATCC 25923 (S. aureus) and gram-negative bacteria Escherichia coli ATCC 25922 (E. coli). Good antibacterial activities were observed for all tested copolymers. It was demonstrated that gram-positive bacteria were more sensitive than gram-negatives, and KFCQ agent was more active than KFB and KFC‎‎.

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Pharmacophore
ISSN: 2229-5402


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