SARS-CoV-2 was widely spread early in 2020. It causes unknown pneumonia with different organ complications. An increase in the liver enzymes activity and renal parameters were the most common problems associated with the SARS-CoV-2 infection. Studies reported the correlation between the increase in the liver enzyme activity AST and CRP and ferritin with reporting the correlation with Di-Dimer. This study aims to investigate the correlation between liver enzymes (AST and ALT) and renal parameters with laboratory parameters (D-Dimer, Ferritin, and CRP). Blood samples were withdrawn from 77 (35 controls and 42 patients) to investigate the liver enzymes, renal parameters, blood sugar, and laboratory parameters (D-Dimer, Ferritin, and CRP). The relationship between the increase in the liver enzymes and renal parameters with laboratory parameters increases with the SARS-Co-V-2 infection. 16 (38%) out of 42 patients were associated with severe SARS-CoV-2 illness. Liver enzymes activity ALT and AST were increased in 23 (55%) and 20 (48%) patients respectively. Renal parameters were increased in 16 (38%) patients. Only 11 out of 16 patients were suffering from severe illnesses and had an increase in liver enzymes activity, while only 7 (17%) patients had severe illnesses and an increase in renal parameters. AST activity had a negative correlation with D-Dimer. This study concluded that the increase in AST correlated negatively with the increase in D-Dimer in SARS-CoV-2 patients.