The present study was carried out to assess the anthelmintic activity of Pergularia daemia leaves. The different extracts of Pergularia daemia leaves were evaluated separately on earthworm (Eudrillus eugeniae), roundworm (Ascaris lumbricoides) and tapeworm (Taenia solium) using albendazole as reference standard. The extracts caused paralysis followed by the death of warms at tested dose levels. The both extracts at the highest tested concentration significantly exhibits (P<0.01) paralysis and also caused death of worms as comparable with that of standard drug albendazole. The study displayed that ethanol extract of Pergularia daemia leaves shown most significant anthelmintic activity than the aqueous extract. Further studies are suggested to isolate the active principles from the plant extracts responsible for the activity.