Investigation of Tumor Budding in Oral Squamous Cell Carcinoma Download PDF

Background: Limited studies have been carried out on Tumor Budding in oral squamous cell carcinoma (OSCC). The present study evaluated the correlation between tumor budding and clinicopathologic factors in OSCC samples. Materials and methods: Microscopic sections of 90 samples with definitive diagnosis of OSCC were evaluated. The clinicopathologic factors, were recorded and microscopic sections were evaluated the presence and scoring of tumor budding. Data were analyzed at a significance level of P<0.05. Results: The 90 evaluated samples were consisted of 32 (36%) females and 58 (64%) males with age of 60 ±16 years old. The most common location was tongue as 38 cases (42.2%). 33% & 67% of investigated samples had low & high tumor budding, respectively. There was no significant correlation between tumor budding and patients’ age and gender (P=0.54 & 0.88, respectively). Lymph node involvement, vascular invasion, grading and tumor size had significant correlation with tumor budding (P=0.0001). Also, there was a significant correlation between tumor budding and the depth of invasion (P=0.025). Based on Spearman’s correlation coefficient, there was a positive correlation between all the factors evaluated in the present study except for age and gender. Conclusion: The present study showed evaluation of tumor budding can be helpful to prediction of OSCC clinical behavior.