The term "ischemia" refers to a localized loss of blood flow (circulation) caused by a blockage of the blood vessels supplying the area. Only 44% of women are aware that CVD is the biggest cause of mortality for women, down from 65% in 2009, according to the results of a 2019 survey. This study aims to assess the awareness and knowledge of Saudi population about the risk of ischemic heart disease (IHD) in post-menopausal women. The study was a community-based cross-sectional study among the Saudi post-menopausal-women population who can read Arabic or English, and have the will to participate in the study were included. The data was collected via a valid and reliable questionnaire that was distributed to participants. Quantitative data were analyzed using the t-test, and the Chi-square test and was used to assess qualitative variables. A P value of ≤ 0.05 is considered significant. Statistical analysis was performed with IBM SPSS version 29.0 Statistical software package. The study included 449 participants, 51.4% of whom were males. 39.2% of the respondents have a high degree of knowledge and awareness of ischemic heart disease risk among post-menopausal women, while 32.3% have a moderate level, and 28.5% have poor knowledge and awareness. Overall, the Saudi general population had inadequate knowledge of ischemic heart disease risk among post-menopausal women. Age, educational level, monthly income, and occupation were significantly associated with participants’ knowledge.