Two sesquiterpene lactones; xanthanolides, isolated and their structures were established by spectroscopic methods (IR, 1H – NMR, 13C – NMR and Lc-Ms spectra). Antisuppresent activity and antimicrobial study, Were carried out the isolated isoxanthanol has got significant antisuppresent activity as compared to control and standard were as xanthanol has got moderate activity compared to control and standard. But the isolated compounds does not show any significant antimicrobial activity compared to control and standard.