The purpose of the research is to predict job stress in female nurses based on distress tolerance and sense of humor. The research method is of a correlational type. The statistical population of this study included all nurses of Shiraz hospitals. A sample of 180 female nurses from Al-Zahra heart hospital in Shiraz was selected by convenient sampling method. The data was collected using Nursing job stress questionnaire by Toft Gary and Anderson, Distress Tolerance Scale (DTS), and Sense of Humor Questionnaire (SHQ). The findings were analyzed by statistical tests of multivariate regression analysis and Pearson correlation test. The results showed that the level of distress tolerance and sense of humor are able to negatively predict job stress in nurses.
