Topical steroids (TS) are commonly used anti-inflammatory medications in patients with dermatological conditions, such as eczema and psoriasis. If topical steroids are administered improperly or extensively, serious side effects may result. According to numerous papers conducted, the misuse of topical steroids is a widespread issue worldwide. This study aims to assess the knowledge and awareness level in Saudi Arabia regarding the adverse effects and complications of TS. This study is a cross-sectional study conducted in Saudi Arabia, using an online survey from 2023 to 2024. The questions of the survey analyze the basic knowledge and awareness of the adverse effects of using topical steroids. The study included 461 participants, 69.6% of whom were females. A majority of the respondents have not used topical cortisone, with 59% indicating that they haven't used it. Among those who have used topical cortisone, the most common reason for usage is for eczema and dermatitis, accounting for 49.2% of responses. This is followed by acne at 26.5% and psoriasis at 13.8%. 34.9% of participants had poor knowledge of the adverse effects of topical steroids, 56.4% had moderate knowledge, and only 8.7% had good knowledge. In conclusion, the study shows that the Saudi general population had inadequate knowledge and awareness about the adverse effects of topical steroids. This is a critical issue that needs to be addressed through targeted education and awareness campaigns.